Intensity matters: Ryanodine receptor regulation during exercise
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چکیده
منابع مشابه
Intensity matters: Ryanodine receptor regulation during exercise.
Tobias Kohl, Gunnar Weninger, Ran Zalk, Philip Eaton, and Stephan E. Lehnart Heart Research Center Göttingen, Clinic of Cardiology & Pulmonology, University Medical Center & Georg-August-University, 37099 Göttingen, Germany; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel; King’s College London, Cardiovascular Division, The Bri...
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The cardiac type 2 ryanodine receptor (RYR2) is activated by Ca2+-induced Ca2+ release (CICR). The inherent positive feedback of CICR is well controlled in cells, but the nature of this control is debated. Here, we explore how the Ca2+ flux (lumen-to-cytosol) carried by an open RYR2 channel influences its own cytosolic Ca2+ regulatory sites as well as those on a neighboring channel. Both flux-d...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2015
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1521051112